Tetrahedron

Microbial transformations: Part 4 (1) Regioselective para hydroxylation of aromatic rings by the fungus beauveriasulfurescens the metabolism of isopropyl n-phenyl

B Vigne, A Archelas, JD Fourneron, R Furstoss

Index: Vigne; Archelas; Fourneron; Furstoss Tetrahedron, 1986 , vol. 42, # 9 p. 2451 - 2456

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Citation Number: 37

Abstract

A specific para hydroxylation of the aromatic ring of isopropyl N-phenyl carbamate 1 by the fungus Beauveria sulfurescens has been achieved. Studies of the deuterium labelled compound show high retention (NIH shift) for this transformation, a fact uhich indicates that the mechanism implied is consistent which the intermediate formation of an arene oxide. Also, formation of a glucoside conjugate of the phenol has been observed.