Synlett 2010-12-01

Facile Route to Tetrasubstituted Pyrazoles Utilizing Ceric Ammonium Nitrate.

JamesJ Devery, PramodK Mohanta, BrianM Casey, RobertA Flowers

Index: Synlett (9) , 1490-1494, (2009)

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Abstract

A convenient approach for the synthesis of tetrasubstituted pyrazoles is described. The method involves the treatment of 1,3-diketones and allyltrimethylsilane with CAN followed by cerium-catalyzed addition of substituted hydrazines to construct pyrazoles in good yields.