Chemical Communications 2012-02-11

Enzymatic biofuel cells utilizing a biomimetic cofactor.

Elliot Campbell, Matthew Meredith, Shelley D Minteer, Scott Banta

Index: Chem. Commun. (Camb.) 48(13) , 1898-900, (2012)

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Abstract

The performance of immobilized enzyme systems is often limited by cofactor diffusion and regeneration. Here, we demonstrate an engineered enzyme capable of utilizing the minimal cofactor nicotinamide mononucleotide (NMN(+)) to address these limitations. Significant gains in performance are observed with NMN(+) in immobilized systems, despite a decreased turnover rate with the minimal cofactor.This journal is © The Royal Society of Chemistry 2012