Phytochemistry 2015-03-01

Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata.

Nguyen Tuan Hiep, Jaeyoung Kwon, Dong-Woo Kim, Bang Yeon Hwang, Hak-Ju Lee, Woongchon Mar, Dongho Lee

Index: Phytochemistry 111 , 141-8, (2015)

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Abstract

Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 μM.Copyright © 2014 Elsevier Ltd. All rights reserved.