Bioorganic & Medicinal Chemistry Letters 2004-05-17

Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.

Steven D Linton, Teresa Aja, Peter R Allegrini, Thomas L Deckwerth, Jose-Luis Diaz, Bastian Hengerer, Julia Herrmann, Kathy G Jahangiri, Joerg Kallen, Donald S Karanewsky, Steven P Meduna, Kip Nalley, Edward D Robinson, Silvio Roggo, Giorgio Rovelli, Andre Sauter, Robert O Sayers, Albert Schmitz, Robert Smidt, Robert J Ternansky, Kevin J Tomaselli, Brett R Ullman, Christoph Wiessner, Joe C Wu

Index: Bioorg. Med. Chem. Lett. 14(10) , 2685-91, (2004)

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Abstract

Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein.