Biomeditsinskaia khimiia 2013-01-01

[The effect of berberine administration of evaluation of the functional state of rat liver after ligation of common bile duct].

I V Zverinskiĭ, N G Mel'nichenko, V A Poplavskiĭ, I P Sut'ko, P G Telegin, A G Shliakhtun

Index: Biomed. Khim. 59(1) , 90-6, (2013)

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Abstract

On the eighth day after ligation of the common bile duct in rats a significant increase in the serum content of total lipids, cholesterol bilirubin and ALT, alkaline phosphatase, and gamma-glutamyltransferase was observed. In the microsomal fraction there was a marked decrease in the content and activity of microsomal monooxygenases. Introperitoneal injection of berberine (10 mg/kg) for 6 days caused a partial normalization of permeability of hepatocytes plasma membranes and activity microsomal flavin-containing monooxygenases. It is suggested that berberine is a substrate and inducer of flavin-containing monooxygenases. Membrane-stabilizing effect of berberine is probably realized at the level of inhibition of prooxidant status of liver cells.