Chemico-Biological Interactions 2013-04-25

Donor substrate specificity of bovine kidney gamma-glutamyltransferase

Anita A. Agblor, P. David Josephy

Index: Chem. Biol. Interact. 203(2) , 480-5, (2013)

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Abstract

Highlights • Five aromatic or polycyclic aromatic glutathione conjugates were synthesized. • Enzyme kinetic studies were performed for each conjugate as a γ-glutamyltransferase (GGT) donor substrate. • All conjugates tested were substrates for GGT, with a possible trend towards higher Km values for bulkier substrates. • These results clarify the ability of GGT to act in the biotransformation of aromatic compounds.