e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis and biological evaluations of quinoline-based HMG-CoA reductase inhibitors

M Suzuki, H Iwasaki, Y Fujikawa, M Kitahara…

Index: Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743

Full Text: HTML

Citation Number: 94

Abstract

... Bioorganic & Medicinal Chemistry. ... discovery of the naturally occurring fungal metabolites compactin 2a,b and lovastatin, 2c,d and the microbially transformed pravastatin, 2e a HMG-CoA reductase inhibitor has been the most attractive target for medicinal researchers. ... Chemistry. ...

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Structure

2-Cyclopropyl-4...

~%

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate Structure

Ethyl (E)-7-[4-...

2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde Structure

2-Cyclopropyl-4...

~%

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate Structure

Ethyl (E)-7-[4-...

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile Structure

(E)-3-[2-Cyclop...

~%

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate Structure

Ethyl (E)-7-[4-...

2-Amino-4'-fluorobenzophenone Structure

2-Amino-4'-fluo...

~%

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate Structure

Ethyl (E)-7-[4-...

Methyl 3-cyclopropyl-3-oxopropanoate Structure

Methyl 3-cyclop...

~%

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate Structure

Ethyl (E)-7-[4-...

Methyl 4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinecarboxylate Structure

Methyl 4-(4'-fl...

~%

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate Structure

Ethyl (E)-7-[4-...

2-cyclopropyl-4-(4-fluorophenyl)-6,7-dimethoxyquinoline-3-carbaldehyde Structure

2-cyclopropyl-4...

~%

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate Structure

Ethyl (E)-7-[4-...

(2-cyclopropyl-4-(4-fluorophenyl)-6,7-dimethoxyquinolin-3-yl)methanol Structure

(2-cyclopropyl-...

~%

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate Structure

Ethyl (E)-7-[4-...

2-cyclopropyl-3-(3-ethoxy-1-hydroxy-2-propenyl)-4-(4-fluorophenyl)quinoline Structure

2-cyclopropyl-3...

~%

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate Structure

Ethyl (E)-7-[4-...

2-cyclopropyl-4-(4-fluorophenyl)-6,7-dimethoxyquinoline-3-carbaldehyde Structure

2-cyclopropyl-4...

~%

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile Structure

(E)-3-[2-Cyclop...

(2-cyclopropyl-4-(4-fluorophenyl)-6,7-dimethoxyquinolin-3-yl)methanol Structure

(2-cyclopropyl-...

~%

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile Structure

(E)-3-[2-Cyclop...

2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde Structure

2-Cyclopropyl-4...

~%

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Structure

(E)-3-[2-Cyclop...

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Structure

2-Cyclopropyl-4...

~%

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Structure

(E)-3-[2-Cyclop...

2-Amino-4'-fluorobenzophenone Structure

2-Amino-4'-fluo...

~%

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Structure

(E)-3-[2-Cyclop...

Methyl 3-cyclopropyl-3-oxopropanoate Structure

Methyl 3-cyclop...

~%

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Structure

(E)-3-[2-Cyclop...

Methyl 4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinecarboxylate Structure

Methyl 4-(4'-fl...

~%

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Structure

(E)-3-[2-Cyclop...

2-cyclopropyl-4-(4-fluorophenyl)-6,7-dimethoxyquinoline-3-carbaldehyde Structure

2-cyclopropyl-4...

~%

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Structure

(E)-3-[2-Cyclop...

(2-cyclopropyl-4-(4-fluorophenyl)-6,7-dimethoxyquinolin-3-yl)methanol Structure

(2-cyclopropyl-...

~%

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Structure

(E)-3-[2-Cyclop...

2-Amino-4'-fluorobenzophenone Structure

2-Amino-4'-fluo...

~%

2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde Structure

2-Cyclopropyl-4...

Methyl 3-cyclopropyl-3-oxopropanoate Structure

Methyl 3-cyclop...

~%

2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde Structure

2-Cyclopropyl-4...

Methyl 4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinecarboxylate Structure

Methyl 4-(4'-fl...

~%

2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde Structure

2-Cyclopropyl-4...

Methyl 4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinecarboxylate Structure

Methyl 4-(4'-fl...

~%

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Structure

2-Cyclopropyl-4...

Methyl 3-cyclopropyl-3-oxopropanoate Structure

Methyl 3-cyclop...

~%

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Structure

2-Cyclopropyl-4...

2-Amino-4'-fluorobenzophenone Structure

2-Amino-4'-fluo...

~%

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Structure

2-Cyclopropyl-4...

Synthesis and biological evaluations of quinoline-based HMG-...

[Suzuki; Iwasaki; Fujikawa; Kitahara; Sakashita; Sakoda Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2727 - 2743]