Abstract Addition of hypobromic acid to styrene afforded styrene bromohydrin (I) which was dehydrated to ω-bromostyrene (II). Prince reaction of II with aqueous formaldehyde gave 5- bromo-4-phenyl-1, 3-dioxane (III). The bromine atom in III was replaced with amino group by treatment with methanolic ammonia at 150 C and 6–8 MPa and the obtained threo-5-amino- 4-phenyl-1, 3-dioxane (IVa) was hydrolyzed to give (±)-threo-2-amino-1-phenyl-1, 3- ...
