Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV

…, D Vullo, A Maresca, A Scozzafava, CT Supuran

Index: Carta, Fabrizio; Vullo, Daniela; Maresca, Alfonso; Scozzafava, Andrea; Supuran, Claudiu T. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 6 p. 1564 - 1569

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Citation Number: 20

Abstract

Using hydroxy-/dihydroxybenzoic acids as leads, a series of methyl, ethyl and iso-propyl esters of 4-hydroxy-benzoic acid, 2, 4-, 2, 5-, 2, 6-, 3, 4-, and 3, 5-dihydroxybenzoic acids and of coumaric acid, were obtained and investigated for the inhibition of six mammalian carbonic anhydrase (CA, EC 4.2. 1.1) isoforms, that is, the cytosolic CA I, II and VII, and the transmembrane CA IX, XII and XIV, many of which are established drug targets. Other ...