Investigations into the synthesis of sulfoanalogs of ~-aminobutyric acid (GABA) are related to the search for new biologically active compounds. A comparative study of the sedative (calming) effects of GABA and homotaurine showed that the latter compound is more active [I]. As is known, introduction of an aryl substituent at the 13 position with respect to the acid group can significantly modify the biological activity of the compound. This was recently con- ...
