Synthesis and biological characterisation of novel dithiocarbamate containing 5-nitroimidazole 99m Tc-complexes as potential agents for targeting hypoxia

J Giglio, S Fernández, A Rey, H Cerecetto

Index: Giglio, Javier; Fernandez, Soledad; Rey, Ana; Cerecetto, Hugo Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 394 - 397

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Citation Number: 29

Abstract

With the aim to develop new potential 99mTc-radiopharmaceuticals for imaging hypoxia based on the formation of Tc-nitrido complexes, two novel dithiocarbamate containing metronidazole derivatives (L1 and L2) have been prepared and characterised. The synthesis of L1 and L2 was achieved in excellent yield and high purity. Labelling with 99mTc was successfully performed using a low ligand concentration (approximately 2–3mg) and ...