Tetrahedron

Asymmetric synthesis of phosphonic acid analogues for acylcarnitine

T Yamagishi, K Fujii, S Shibuya, T Yokomatsu

Index: Yamagishi, Takehiro; Fujii, Keiichi; Shibuya, Shiroshi; Yokomatsu, Tsutomu Tetrahedron, 2006 , vol. 62, # 1 p. 54 - 65

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Citation Number: 15

Abstract

Phosphonic acid analogues of acylcarnitine were prepared in an optically active form expecting CPT I inhibitory activities. The synthetic methodology was based on catalytic asymmetric dihydroxylation of β, γ-unsaturated phosphonates and subsequent regioselective amination via the cyclic sulfates.