Abstract The 1 H and the noise-decoupled 13 C NMR spectra of isochromane and 13 of its methyl-substituted derivatives were recorded and analysed. The collected data were used to assign the configurations and to determine the position of the conformational equilibria based on the vicinal 1 H coupling constants of the aliphatic moiety of the ring system. In some cases the substitution site-dependent conformational energies of the methyl ...
