Tetrahedron

First straightforward synthesis of 2, 4-disubstituted benz [g] isoquinoline-3, 5, 10 (2H)-triones, 1, 2, 3, 5-substituted naphtho [3, 2, 1-de] isoquinoline-4, 7-diones, and 6- …

J Jacobs, B Kesteleyn, N De Kimpe

Index: Jacobs, Jan; Kesteleyn, Bart; De Kimpe, Norbert Tetrahedron, 2008 , vol. 64, # 32 p. 7545 - 7554

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Citation Number: 12

Abstract

Structural modifications to the benz [g] isoquinoline skeleton of N-substituted benz [g] isoquinoline-3, 5, 10 (2H)-triones were envisaged in order to make future SAR studies possible for this type of bioactive compounds. Several N-substituted benz [g] isoquinoline-3, 5, 10 (2H)-triones were converted to novel 2, 4-substituted benz [g] isoquinoline-3, 5, 10 (2H)-triones, new tetracyclic 1, 2, 3, 5-substituted naphtho [3, 2, 1-de] isoquinoline-4, 7- ...