Biotransformation of 3-(phenylamino)-1, 2-propanediol to 3-(phenylamino) alanine: a chemical link between toxic oil syndrome and eosinophilia-myalgia syndrome

…, S Naylor, M Colberg-Beers, JT Puchalski…

Index: Mayeno, Arthur N.; Benson, Linda M.; Naylor, Stephen; Colberg-Beers, Marelisa; Puchalski, Jonathan T.; Gleich, Gerald J. Chemical Research in Toxicology, 1995 , vol. 8, # 7 p. 911 - 916

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Citation Number: 39

Abstract

During late 1989, the eosinophilia-myalgia syndrome (EMS) developed as an epidemic in the United States, with numerous additional cases reported in several other countries worldwide. Eight years earlier, a closely-related disease, the toxic oil syndrome (TOS), occurred in Spain as a massive food-borne epidemic. Although EMS was linked to the ingestion of tainted L-tryptophan, and TOS to aniline-denatured rapeseed oil, the etiologic ...