The syntheses of models for a study of acetylcholinesterase (AChE) binding are described. 6- (N, N, N-Trimethy1ammonium) indan-1-one iodide (4) as a muscarinic agent possessed'/io0 the activity of acetylcholine. As an inhibitor of AChE (eel) the calculated Ki for 4 was 1.6 X 10- 7M. 4-(N, N, N-Trimethylammonium) indan-1-one iodide (S), 3-(N, N, N-trimethylammonium) propiophenone iodide (6), and 3-
