Spirocyclic NK 1 antagonists I:[4.5] and [5.5]-Spiroketals

…, E Carlson, T Harrison, KE Haworth, R Herbert…

Index: Seward, Eileen M; Carlson, Emma; Harrison, Timothy; Haworth, Karen E.; Herbert, Richard; Kelleher, Fintan J.; Kurtz, Marc M.; Moseley, Jonathan; Owen, Simon N.; Owens, Andrew P.; Sadowski, Sharon J.; Swain, Christopher J.; Williams, Brian J. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2515 - 2518

Full Text: HTML

Citation Number: 17

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of novel spiroketal-based NK 1 antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration. ... A series of novel spiroketal-based NK 1 ...