Synthesis of Enantiomerically??Pure [13C] Aristeromycylcobalamin and Its Reactivity in Dioldehydratase, Glyceroldehydratase, Ethanolamine Ammonia??Lyase and …

…, M Heimberger, AJ Pierik, J Rétey

Index: Weigl, Ulrich; Heimberger, Martin; Pierik, Antonio J.; Retey, Janos Chemistry - A European Journal, 2003 , vol. 9, # 3 p. 652 - 660

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Citation Number: 10

Abstract

Abstract We describe a novel enantioselective synthesis of aristeromycin, the carbocyclic analogue of adenosine. The seven-step synthesis is also suitable for the preparation of specifically-labelled [6′-13 C] aristeromycin. Both the unlabelled and 13 C-labelled product was coupled to vitamin B 12 to form aristeromycylcobalamin. This carbocyclic analogue of coenzyme B 12 was examined for its coenzymic activity with several adenosylcobalamin- ...