Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR)

CS Takeuchi, BG Kim, CM Blazey, S Ma…

Index: Journal of Medicinal Chemistry, , vol. 56, # 6 p. 2218 - 2234

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Citation Number: 15

Abstract

... Journal of Medicinal Chemistry. ... Chem. , 2013, 56 (6), pp 2218–2234. DOI: 10.1021/ jm3007933. Publication Date (Web): February 8, 2013. Copyright © 2013 American Chemical Society. *Phone: 82-2-470-9602 (BGK); (813) 974-4642 (JWL). ...

Discovery of a novel class of highly potent, selective, ATP-...

[Takeuchi, Craig S.; Kim, Byung Gyu; Blazey, Charles M.; Ma, Sunghoon; Johnson, Henry W. B.; Anand, Neel K.; Arcalas, Arlyn; Baik, Tae Gon; Buhr, Chris A.; Cannoy, Jonah; Epshteyn, Sergey; Joshi, Anagha; Lara, Katherine; Lee, Matthew S.; Wang, Longcheng; Leahy, James W.; Nuss, John M.; Aay, Naing; Aoyama, Ron; Foster, Paul; Lee, Jae; Lehoux, Isabelle; Munagala, Narsimha; Plonowski, Arthur; Rajan, Sharmila; Woolfrey, John; Yamaguchi, Kyoko; Lamb, Peter; Miller, Nicole Journal of Medicinal Chemistry, 2013 , vol. 56, # 6 p. 2218 - 2234]