Synthesis, biological evaluation, and binding mode of novel 1-[2-(diarylmethoxy) ethyl]-2-methyl-5-nitroimidazoles targeted at the HIV-1 reverse transcriptase

R Silvestri, M Artico, G De Martino…

Index: Massa; Stefancich; Corelli; Silvestri; Panico; Artico; Simonetti Farmaco, Edizione Scientifica, 1988 , vol. 43, # 9 p. 693 - 704

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Citation Number: 71

Abstract

A novel series of 1-[2-(diarylmethoxy) ethyl]-2-methyl-5-nitroimidazole (DAMNI) analogues were synthesized and tested in cell-based assays and in enzyme assays against HIV-1 recombinant reverse transcriptase (RT). Preparation of the new derivatives was performed