Preparation of Grignard reagents: FTIR and calorimetric investigation for safe scale-up

…, PJ Clifford, DM DeAntonis, C SantaMaria…

Index: Ende, David J.; Clifford, Pamela J.; Deantonis, David M.; Santamaria, Charles; Brenek, Steven J. Organic Process Research and Development, 1999 , vol. 3, # 5 p. 319 - 329

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Citation Number: 41

Abstract

Preparation of Grignard reagents from organic halides and magnesium pose potential safety hazards on scale-up due to their high exothermic potential which can lead to overpressurization, discharge of contents, or explosion. One of the main challenges arises in ensuring the reaction has initiated before excessive accumulation of organic halide occurs or that the reaction does not stall and then reinitiate. Specifically, in production-scale ...