Tetrahedron letters

Chiral synthesis of isocarbacyclin ((+)-9 (0)-methano-Δ 6 (9α)-PGI 1) intermediate via rhodium (II)-catalyzed intramolecular C H insertion reaction

S Hashimoto, T Shinoda, Y Shimada, T Honda…

Index: Hashimoto, Shun-ichi; Shinoda, Tomohiro; Shimada, Yasunaga; Honda, Takeshi; Ikegami, Shiro Tetrahedron Letters, 1987 , vol. 28, # 6 p. 637 - 640

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Citation Number: 25

Abstract

A key intermediate for the synthesis of isocarbacyclin, a promising therapeutic agent for cardiovascular and circulatory disorders, has been synthesized from ( )-(+)-methyl 2-oxo-1-cyclopentaneacetate by employing rhodium(II)-catalyzed intramolecular CH insertion reaction of α-diazo β-keto ester as a key step. ... A key intermediate for the synthesis of isocarbacyclin has been synthesized from (R)-(+)-methyl 2-oxo-1-cyclopentaneacetate by employing rhodium(II)-catalyzed ...