Biosynthesis of the lincomycins. 1. Studies using stable isotopes on the biosynthesis of the propyl-and ethyl-L-hygric acid moieties of lincomycins A and B

NM Brahme, JE Gonzalez, JP Rolls…

Index: Brahme; Gonzalez; Rolls; et al. Journal of the American Chemical Society, 1984 , vol. 106, # 25 p. 7873 - 7878

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Citation Number: 43

Abstract

Abstract: The biosynthesis of the propyl-L-hygric acid and ethyl-L-hygric acid moieties of lincomycins A and B has been examined by using deuterated and carbon-13 labeled precursors in combination with carbon-13 NMR and mass spectral analysis. The results, using specifically deuterated tyrosine, DOPA, and methionine, demonstrate that tyrosine is converted via DOPA to an intermediate that undergoes aromatic ring cleavage most ...