Identification and characterization of a potential ischemia-selective N-methyl-d-aspartate (NMDA) receptor ion-channel blocker, CNS 5788

S Padmanabhan, ME Perlman, L Zhang…

Index: Padmanabhan, Seetharamaiyer; Perlman, Michael E; Zhang, Lu; Moore, Deke; Zhou, Dan; Fischer, James B; Durant, Graham J; McBurney, Robert N Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 501 - 504

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Citation Number: 8

Abstract

The identification and characterization of a potentially ischemia-selective and orally-active sulfoxide based NMDA ion-channel blocker showing good neuroprotective activity,(R)-(+)-N- (2-chloro-5-methylthiophenyl)-N′-(3-methylsulfinylphenyl)-N′-methylguanidine (CNS 5788), is described.