Abstract A procedure has been proposed for the synthesis of 2-(cyclopentylsulfanyl)-6-[(1 R)- 1-(2, 6-difluorophenyl) ethyl]-5-methylpyrimidin-4 (3 H)-one through intermediate (3 R)-4, 4- dimethyl-2-oxotetrahydrofuran-3-yl (2 R)-2-(2, 6-difluorophenyl) propanoate which was obtained from prochiral 2-(2, 6-difluorophenyl) prop-1-en-1-one generated in situ. The proposed procedure may be regarded as stereoselective route to 6-[(1 R)-1-(2, 6- ...
