Ligand??Free Copper??Catalyzed One??Pot Synthesis of Indole??2??carboxylic Esters

…, J Yuan, Y Zhou, Y Qin, J Xu, Y Peng

Index: Zhu, Zhiqiang; Yuan, Jiangjun; Zhou, Yirong; Qin, Yang; Xu, Jingshi; Peng, Yiyuan European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 511 - 514

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Citation Number: 2

Abstract

Abstract A simple, efficient, and facile synthetic route for the preparation of indole-2- carboxylic esters was described. The cascade reactions of 2-bromobenzaldehyde and glycine ester hydrochloride were promoted by Cu 2 O and a base to provide the corresponding products in good yields. Commercially available, inexpensive substrates and reagents were employed under mild reaction conditions in this one-pot operation, which is ...