Molecules

Synthesis and adrenolytic activity of new propanolamines

G Groszek, A Bajek, A Bis, A Nowak-Król, M Bednarski…

Index: Groszek, Grazyna; Bajek, Agata; Bis, Agnieszka; Nowak-Krol, Agnieszka; Bednarski, Marek; Siwek, Agata; Filipek, Barbara Molecules, 2010 , vol. 15, # 6 p. 3887 - 3904

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Abstract

Abstract The synthesis of (2R, S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2- methoxyphenoxy) ethylamino) propan-2-ol and (2R, S)-1-(4-methoxy-6-(methoxymethyl)-1H- indol-5-yloxy)-3-(2-(2-methoxyphenoxy) ethylamino) propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for a 1-, a 2-and β 1-adrenoceptor binding affinity. Keywords: