Thienopyrimidine-based P2Y 12 platelet aggregation inhibitors

…, RM Lachance, BA Schweitzer, G Yalamanchili…

Index: Kortum, Steven W.; Lachance, Rhonda M.; Schweitzer, Barbara A.; Yalamanchili, Gopichand; Rahman, Hayat; Ennis, Michael D.; Huff, Rita M.; TenBrink, Ruth E. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 20 p. 5919 - 5923

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Citation Number: 20

Abstract

... Other users also viewed these articles. Opens document download manager. Do not show again. Downloading zip file containing 3 articles... ... Synthesis of the thienopyrimidine cores 5 and 7. Reagents and conditions: (a) sulfur, triethylamine, DMF, rt, 18 h (70%); (b) acetic acid, H 2 O, KOCN, rt, 18 h (64%); (c) phenylphosphonic dichloride, 150 °C, 3 h (95%); (d) formamide, ammonium formate, 135 °C, 12 h (75%); (e) thionyl chloride, DMF, 80 °C, 3 h (86%). ...