Rapid generation of privileged substructure-based compound libraries with structural diversity and drug-likeness

L Zhang, M Zheng, F Zhao, Y Zhai…

Index: Zhang, Lei; Zheng, Mingyue; Zhao, Fei; Zhai, Yun; Liu, Hong ACS Combinatorial Science, 2014 , vol. 16, # 4 p. 184 - 191

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Citation Number: 16

Abstract

A library of privileged-substructure-based, heterocyclic compounds was constructed by a sequence of Ugi four-component reactions incorporating the indole motif and microwave- assisted cyclizations in branched pathways. Cheminformatic analysis confirmed that the library exhibited a high degree of structural diversity and good drug-likeness.