An estradiol-conjugate for radiolabelling with 177 Lu: an attempt to prepare a radiotherapeutic agent

S Banerjee, T Das, S Chakraborty, G Samuel…

Index: Banerjee, Sharmila; Das, Tapas; Chakraborty, Sudipta; Samuel, Grace; Korde, Aruna; Venkatesh, Meera; Pillai Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 13 p. 4315 - 4322

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Citation Number: 19

Abstract

177Lu is presently being considered as one of the most promising radionuclide for targeted therapy owing to its suitable decay characteristics. 177Lu in high radionuclidic purity (99.99%) and moderate specific activity (100–110TBq/g) was produced using enriched (60.6% 176Lu) Lu2O3 target. The macrocycle 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10- tetraacetic acid (DOTA) is known to form stable complexes with lanthanides. Herein, we ...