The Journal of organic chemistry

Fully stereocontrolled syntheses of 3-oxacarbacyclin and carbacyclin by the conjugate addition-azoalkene-asymmetric olefination strategy

M Kim, HJ Gais

Index: Iseki; Mase; Okazaki; et al. Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4448 - 4455

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Citation Number: 19

Abstract

... the attention of chemistry, biology, and medicine ever since its discovery in 1976 by Vane et al. ... While the chemical instability of prostacyclin is caused by a fast hydration of the enol ... prostaglandin synthesis by the conjugate addition-enone strategy 2a,d,29 has made available a ...