In an attempt to design and synthesize potential anticancer agents acting by inhibition of topoisomerase I (top1), a new series of indenoisoquinolines was prepared and tested for cytotoxicity in human cancer cell cultures and for activity against top1. The synthesis relied on the condensation of substituted Schiff bases with homophthalic anhydrides to produce cis- 3-aryl-4-carboxyisoquinolones that were cyclized to indenoisoquinolines in the presence ...
![6-(3-chloropropyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione Structure](https://image.chemsrc.com/caspic/151/308246-42-6.png)
