Synthesis and structure-activity relations of heterocyclic compounds containing a trimethoxyarene function

EA Mawdsley, KD Berlin, RW Chesnut…

Index: Mawdsley,E.A. et al. Journal of Medicinal Chemistry, 1976 , vol. 19, # 2 p. 239 - 243

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Citation Number: 9

Abstract

1 (2H)-phenanthrone. Primarily, the pyrazoles displayed inhibition of growth in the microbial screens and in tissue culture. Correlation of the heteroatom distances between the oxygen atoms of two methoxy groups and a nitrogen atom in the pyrazole function with the percent plating efficiency on KB cell growth suggests increased inhibition as the (OA-N)/(OBN) ratio deviates from one. No trend was observed in relating the 0-4-N-OB angle and activity for ...