Synthesis of a Fragment A Derivative of an Antibiotic, Nosiheptide.

…, H Noda, J Yoshimura, A Konn, Y Yonezawa…

Index: Umemura, Kazuyuki; Noda, Hirofumi; Yoshimura, Juji; Konn, Akihito; Yonezawa, Yasuchika; Shin, Chung-Gi Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 6 p. 1391 - 1396

Full Text: HTML

Citation Number: 24

Abstract

Two 4-ethoxycarbonyl thiazolyl groups were introduced into 2-and 5-positions of 3- hydroxypyridine in 8 steps using 5-cyano-3-hydroxypyridine (2) as the starting material. The pyridine derivative obtained in the last step was converted to a fragment A derivative (21) by stepwise introduction of the 2-substituted 4-thiazolyl group into the 6-position. The total yield for the formation of 21 via 14 steps was 7.6%.