Scaffold hopping approach towards various AFQ-056 analogs as potent metabotropic glutamate receptor 5 negative allosteric modulators

H Kubas, U Meyer, M Hechenberger, KU Klein…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 23 p. 6370 - 6376

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Citation Number: 2

Abstract

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. ... 1). However, no marketed mGluR5 drug has yet evolved, and there is a continuing demand of additional chemical lead structures. ...