Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro [3.5] nonane urea PF-04862853, an orally efficacious …

MJ Meyers, SA Long, MJ Pelc, JL Wang…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 21 p. 6545 - 6553

Full Text: HTML

Citation Number: 18

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Having identified two optimal spirocyclic cores, we outlined a parallel medicinal chemistry optimization strategy relying heavily on design of small, iterative compound libraries (∼50 analogs/library) to optimize both the lipophilic tail ...