2-Arylamino-4-oxo-3, 4-dihydropyrido [2, 3-d] pyrimidines: synthesis and diuretic activity

…, V Martinez-Merino, C Sanmartin, FJ Fernandez…

Index: Monge, Antonio; Martinez-Merino, Victor; Sanmartin, Carmen; Fernandez, Francisco J.; Ochoa, Maria C. European Journal of Medicinal Chemistry, 1989 ,  vol. 24, p. 209 - 216

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Citation Number: 49

Abstract

Abstract The synthesis of a series of 19 new compounds, 2-arylamino-4-oxo-3, 4- dihydropyrido [2, 3-d] pyrimidines 9, and the results of a study of their potassium-sparing diuretic activity are reported. Compounds 9 were obtained by boiling in dimethylformamide a solution of 2-methylthio-4-oxo-3, 4-dihydropyrido [2, 3-d] pyrimidine hydrochloride (5 HCl, method A) or 2-chloro-4-oxo-3, 4-dihydropyrido [2, 3-d] pyrimidine hydrochloride (8 HCl, ...