Preparation and utilization of chiral dihydropyridines. Synthesis of chiral indoloquinolizines and benzoquinolizines

…, S Raussou, M Commercon, A Alexakis

Index: Mangeney; Gosmini; Raussou; Commercon; Alexakis Journal of Organic Chemistry, 1994 , vol. 59, # 7 p. 1877 - 1888

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Citation Number: 71

Abstract

An asymmetric synthesis of 3-formyl-l, 4-dihydropyridines is described that entails the addition of organocopper reagents to activated 3-imidazolidinylpyridine, prepared with chiral diamines. The activator can be a chloroformate or an acid chloride. The methodology was used for the asymmetric syntheses of the indoloquinolizine and benzoquinolizine alkaloid frameworks.