However, this unsaturated guanosine derivative was not isolated nor characterized and its yield was very low. A structure-activity analysis is provided for several base-modified pyrimidine 3'-azido-2 ', 3 '-dideoxynucleosides (la, Id, le, If, lg) and compared with the previously described compounds lh and li. l0 Although some of these compounds (la, le, lh) were previously described by Lin et a1.: these authors only evaluated them against the ...