Prodrugs based on masked lactones. Cyclization of. gamma.-hydroxy amides

CD Johnson, S Lane, PN Edwards…

Index: Johnson, C. David; Lane, Simon; Edwards, Philip N.; Taylor, Peter J. Journal of Organic Chemistry, 1988 , vol. 53, # 21 p. 5130 - 5139

Full Text: HTML

Citation Number: 28

Abstract

I compound R' R 2 compound R1 R2 Rs R4 a HH a HHH p-C6H4Br b CH3 CH3 b CH3 CH3 H p-CBH4Br d 2-camphyl d cyclohexyl H p-C6H4Br e 2-camphyl CH3 CeH6 f 2-camphyl H pC, H4Br c cyclohexyl C CH3 CH3 CH3 CgH6 will address only the covalent modifications leading to prodrugs. These are compounds that must undergo a chemical transformation in the body, before producing the desired pharmacological effect. Although many prodrugs ...