Recently, we have been interested in assessing the antifungal activity of a series of substituted derivatives of thioflavone (1) l. In general, thioflavones are readily synthesised by two methods; either the direct condensation of a P-keto ester (eg 3) with a thiophenol in polyphosphoric acld, 2 or the cyclisation of a D-substituted cinnamate (eg 5), itself derived from the constituent thiophenol and an appropriate propiolate (eg 4). 3 We have prepared ...
![1-[2-(4-methoxybenzylthio)phenyl]-2-(methylsulfinyl)ethanone Structure](https://image.chemsrc.com/caspic/291/117968-39-5.png)