e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis of 26, 27-dialkyl analogues of 1. ALPHA., 25-dihydroxyvitamin D3.

江口正，斎洋之，高津戸秀，原典之…

Index: Eguchi; Sai; Takatsuto; Hara; Ikekawa Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 7 p. 2303 - 2311

Full Text: HTML

Citation Number: 12

Abstract

... (see, A. Honda, 1. Morita, S. Murota, and Y. Mori, Biochim. Biophys. Acta, 877, 423 (1986)). 20) N. Ikekawa, T. Eguchi, N. Hara, S. Takatsuto, A. Honda, Y. Mori, and S. Otomo, Chem. Pharm. Bull., 35, 4362 (1987). ... 1986 (see, N. lkekawa, S. Takatsuto, H. Sai, N. Hara, A. Honda ...

1α,3β-bis(methoxymethoxy)chol-5-en-24-ol Structure

1α,3β-bis(metho...

~%

(R)-5-((1S,3R,8S,9S,10R,13R,14S,17R)-1,3-bis(methoxymethoxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)hexanoic acid Structure

(R)-5-((1S,3R,8...

1α,2α-epoxy-24-tetrahydropyranyloxychola-4,6-dien-3-one Structure

1α,2α-epoxy-24-...

~%

(R)-5-((1S,3R,8S,9S,10R,13R,14S,17R)-1,3-bis(methoxymethoxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)hexanoic acid Structure

(R)-5-((1S,3R,8...

2-(((R)-4-((1S,3R,8S,9S,10R,13R,14S,17R)-1,3-bis(methoxymethoxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentyl)oxy)tetrahydro-2H-pyran Structure

2-(((R)-4-((1S,...

~%

(R)-5-((1S,3R,8S,9S,10R,13R,14S,17R)-1,3-bis(methoxymethoxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)hexanoic acid Structure

(R)-5-((1S,3R,8...

1α,3β-bis(methoxymethoxy)chol-5-en-24-ol Structure

1α,3β-bis(metho...

~%

1α,3β-bis(methoxymethoxy)-26,27-bisnorcholest-5-en-25-oic acid methyl ester Structure

1α,3β-bis(metho...

1α,2α-epoxy-24-tetrahydropyranyloxychola-4,6-dien-3-one Structure

1α,2α-epoxy-24-...

~%

1α,3β-bis(methoxymethoxy)-26,27-bisnorcholest-5-en-25-oic acid methyl ester Structure

1α,3β-bis(metho...

2-(((R)-4-((1S,3R,8S,9S,10R,13R,14S,17R)-1,3-bis(methoxymethoxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentyl)oxy)tetrahydro-2H-pyran Structure

2-(((R)-4-((1S,...

~%

1α,3β-bis(methoxymethoxy)-26,27-bisnorcholest-5-en-25-oic acid methyl ester Structure

1α,3β-bis(metho...

1α,2α-epoxy-24-tetrahydropyranyloxychola-4,6-dien-3-one Structure

1α,2α-epoxy-24-...

~%

2-(((R)-4-((1S,3R,8S,9S,10R,13R,14S,17R)-1,3-bis(methoxymethoxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentyl)oxy)tetrahydro-2H-pyran Structure

2-(((R)-4-((1S,...

1α,3β-bis(methoxymethoxy)-26,27-diethylcholest-5-en-25-ol Structure

1α,3β-bis(metho...

~84%

26,27-diethylcholest-5-ene-1α,3β,25-triol Structure

26,27-diethylch...

1α,3β-bis(methoxymethoxy)chol-5-en-24-ol Structure

1α,3β-bis(metho...

~%

26,27-diethylcholest-5-ene-1α,3β,25-triol Structure

26,27-diethylch...

1α,2α-epoxy-24-tetrahydropyranyloxychola-4,6-dien-3-one Structure

1α,2α-epoxy-24-...

~%

26,27-diethylcholest-5-ene-1α,3β,25-triol Structure

26,27-diethylch...

1α,2α-epoxy-24-tetrahydropyranyloxychola-4,6-dien-3-one Structure

1α,2α-epoxy-24-...

~%

1α,3β-bis(methoxymethoxy)chol-5-en-24-ol Structure

1α,3β-bis(metho...

2-(((R)-4-((1S,3R,8S,9S,10R,13R,14S,17R)-1,3-bis(methoxymethoxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentyl)oxy)tetrahydro-2H-pyran Structure

2-(((R)-4-((1S,...

~%

1α,3β-bis(methoxymethoxy)chol-5-en-24-ol Structure

1α,3β-bis(metho...

Bromo(propyl)magnesium Structure

Bromo(propyl)ma...

1α,3β-bis(methoxymethoxy)-26,27-bisnorcholest-5-en-25-oic acid methyl ester Structure

1α,3β-bis(metho...

~83%

1α,3β-bis(methoxymethoxy)-26,27-diethylcholest-5-en-25-ol Structure

1α,3β-bis(metho...

1α,3β-bis(methoxymethoxy)chol-5-en-24-ol Structure

1α,3β-bis(metho...

~%

1α,3β-bis(methoxymethoxy)-26,27-diethylcholest-5-en-25-ol Structure

1α,3β-bis(metho...

1α,2α-epoxy-24-tetrahydropyranyloxychola-4,6-dien-3-one Structure

1α,2α-epoxy-24-...

~%

1α,3β-bis(methoxymethoxy)-26,27-diethylcholest-5-en-25-ol Structure

1α,3β-bis(metho...

1α,3β-bis(methoxymethoxy)-26,27-bisnorcholest-5-en-25-oic acid methyl ester Structure

1α,3β-bis(metho...

~%

1α,3β-diacetoxy-26,27-diethylcholest-5-en-25-ol Structure

1α,3β-diacetoxy...

1α,3β-bis(methoxymethoxy)chol-5-en-24-ol Structure

1α,3β-bis(metho...

~%

1α,3β-diacetoxy-26,27-diethylcholest-5-en-25-ol Structure

1α,3β-diacetoxy...