Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group

RK Yadlapalli, OP Chourasia, K Vemuri…

Index: Yadlapalli, Rama Krishna; Chourasia; Vemuri, Kiranmayi; Sritharan, Manjula; Perali, Ramu Sridhar Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2708 - 2711

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Citation Number: 31

Abstract

A series of dihydropyrimidine derivatives were synthesized by utilizing Biginelli reaction and evaluated for their in vitro anticancer activity against MCF-7 human breast cancer (HBC) cell line using sulforhodamine B (SRB) assay and antitubercular activity against Mycobacterium tuberculosis (MTB) H37Rv using Microplate Alamar Blue Assay (MABA). Compounds 13p, 13t were exhibited 70.6% and 63.7% of HBC cell growth inhibition at 10μM concentration. ...

~32%

Acetoacetylation with 2, 2, 6-trimethyl-4H-1, 3-dioxin-4-one...

[Clemens, Robert J.; Hyatt, John A. Journal of Organic Chemistry, 1985 , vol. 50, # 14 p. 2431 - 2435]

Transacetoacetylation with tert-butyl acetoacetate: syntheti...

[Witzeman, J. Stewart; Nottingham, W. Dell Journal of Organic Chemistry, 1991 , vol. 56, # 5 p. 1713 - 1718]

Design, synthesis and bioevaluation of dihydropyrazolo [3, 4...

[Fu, Rong-Geng; You, Qi-Dong; Yang, Lei; Wu, Wu-Tong; Jiang, Cheng; Xu, Xiao-Li Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 22 p. 8035 - 8043]