The synthesis of acyl glucuronides of common bile acids is described. By means of the Mitsunobu reaction employing diethylazodicarboxylate and triphenylphosphine, bile acids were condensed through the inherent C-24 carboxy group with benzyl 2, 3, 4-tri-O-benzyl-d- glucopyranuronate, which was prepared from 1-O-methyl-α-d-glucose. The separation and purification of the β-anomers at the anomeric position of the sugar moiety were attained by ...
