A series of 3 '-C-cyano-3 '-deoxynucleosides have been synthesized and evaluated as antiviral agents. Reaction of 2', 5'-bis-O-(tert-butyldimethylsilyl)-~-~-erythro-pentofuranos-3'- ulosyl derivatives of uracil, 4-N-acetylcytosine, and adenine with sodium cyanide gave a mixture of epimeric cyanohydrins, which after 3'-deoxygenation yielded the corresponding 3'- C-cyano-3'-deoxy-~-~-xylo-pentofuranosyl derivatives 10. These compounds were ...
![4-N-acetyl-1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentofuranos-3'-ulosyl]cytosine Structure](https://image.chemsrc.com/caspic/117/121055-63-8.png)
