Summary: Antibiotic elaiophylin 3 has been first synthesized by a convergent route involving aldol condensation between (5R, 6R, 7R)-5-0-[2'-deoxy-3', 4'-di-O-(dimethylisopropylsilyl)- alfucopyranosyl]-6-ethyl-7-O-(diethylisopropylsilyl)-5, 7-dihydroxy-3-octanone 2 and (7S, 8S,