New pyrazolo [1′, 5′: 1, 6] pyrimido [4, 5-d] pyridazin-4 (3H)-ones as potent and selective PDE5 inhibitors

J Feixas, MP Giovannoni, C Vergelli, A Gavaldà…

Index: Feixas, Joan; Giovannoni, Maria Paola; Vergelli, Claudia; Gavalda, Amadeu; Cesari, Nicoletta; Graziano, Alessia; Dal Piaz, Vittorio Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 9 p. 2381 - 2384

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Citation Number: 13

Abstract

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. Volume 15, Issue 9, 2 May 2005, Pages 2381–2384. Cover image Cover image. ... 2. Chemistry. Compounds 10–42 were prepared by following the general procedure reported in Scheme 1. Isoxazolo[3,4-d]pyridazin-7(6H)-one 6 was obtained by treatment with hydrazine of isoxazole 5, following the synthetic procedure reported in the literature. ...