Acyl groups are transferred from diverse N-and O-acyl derivatives of chiral 3, 5-bis-(1- hydroxyethyl)-[1, 2, 4]-triazole to amino acid esters enantioselectively, with 7% to 68% ee, depending on the temperature conditions and nature of the reagents. Thionyl chloride replaced the hydroxyl groups of (S)-1-[4-amino-5-((S)-1-hydroxy-ethyl)-[1, 2, 4]-triazol-3-yl]- ethanol 3 stereospecifically with inversion, as confirmed by X-ray analysis, which also ...
[Cobley, Christopher J; Lennon, Ian C; McCague, Raymond; Ramsden, James A; Zanotti-Gerosa, Antonio Tetrahedron Letters, 2001 , vol. 42, # 42 p. 7481 - 7483]
