Synthesis of cancer peptide antigen-lipid A analog conjugates for synthetic vaccines.

…, K MIYAJIMA, Y MARUYAMA, K ACHIWA

Index: Ikeda, Kiyoshi; Miyajima, Keisuke; Maruyama, Yasufumi; Achiwa, Kazuo Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 4 p. 563 - 568

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Citation Number: 5

Abstract

Conjugates 6 and 7 of cancer peptide antigen with N-tetradecanoly L-serine-β-alanine- containing D-glucosamine derivative structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers. The mitogenic activities of compounds 6 and 7 were stronger than that of lipid A analog 3.